Biocatalysis in natural products chemistry |
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Authors: | F.Sima Sariaslani John P.N. Rosazza |
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Affiliation: | Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA |
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Abstract: | The properties of enzymes and microbial cells as biocatalysts useful in natural products chemistry are discussed from the perspective of the chemical transformations they catalyse. Attention is focused on numerous reactions of value to natural products chemists, including the acyloin condensation, Baeyer-Villiger oxidation, regio- and enantioselective ester hydrolyses, oxidations of aromatic and non-aromatic substrates, oxidoreduction and O- and N-dealkylations. Compounds considered in this review include amino acids, alkaloids, antibiotics, coumarins, naphthoquinones, quassinoids, rotenoids and mono-, sesqui-, di- and triterpenoid substrates. The value of biocatalysis compared with traditional chemical catalysis is considered within the broad framework of natural products chemistry, and the potential for using immobilized enzyme and cell technology is presented. |
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Keywords: | Natural products chemistry biocatalysis microbial transformations enzyme transformations |
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