Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS. |
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| Authors: | S T Roodman M D Woon J W Hoffmann P Theodorakis C C Tsai H N Wu C C Tsai |
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| Affiliation: | Department of Pathology, St. Louis University School of Medicine, MO 63104. |
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| Abstract: | We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor. |
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| Keywords: | Type D simian retrovirus 2 retroperitoneal/subcutaneous fibromatosis PCR autocrine |
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