Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands |
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| Authors: | Zheng Guangrong Dwoskin Linda P Deaciuc Agripina G Crooks Peter A |
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| Institution: | College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA. |
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| Abstract: | A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2. |
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