Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents |
| |
Authors: | Nanduri Srinivas Nyavanandi Vijay Kumar Thunuguntla Siva Sanjeeva Rao Kasu Sridevi Pallerla Mahesh Kumar Ram P Sai Rajagopal Sriram Kumar R Ajaya Ramanujam Rajagopalan Babu J Moses Vyas Krishnamurthi Devi A Sivalakshmi Reddy G Om Akella Venkateswarlu |
| |
Affiliation: | Discovery Chemistry, Dr. Reddy's Laboratories Ltd, Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 049, India. nandurisrinivas@drreddys.com |
| |
Abstract: | Andrographolide 1, the cytotoxic agent of the plant Andrographis paniculata was subjected to semi-synthetic studies leading to the preparation of a number of potent and novel analogues. Of the analogues synthesized, while 8,17-epoxy andrographolide 6 retained the cytotoxic activity of 1, ester derivatives of 6 exhibited considerable improvement in activity. Lower activity was observed when the epoxy moiety in the triacetate 9, derived from 6 was modified. Synthesis and structure-activity relationships are discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|