Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish,Danio rerio: developmental and evolutionary perspectives |
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Authors: | P. Blader U. Strähle Philip W. Ingham |
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Affiliation: | (1) Molecular Embryology, Laboratory ICRF Developmental Biology Unit, Department of Zoology, South Parks Road, Oxford, OX1 3PS, U.K., GB;(2) Molecular Embryology Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, United Kingdom, GB |
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Abstract: | Proteins encoded by the Wnt family of genes act as signals and have been shown to play important roles in a wide variety of developmental processes. Here we describe the cloning of three Wnt family members from the zebrafish, Danio rerio, which encode proteins with homology to murine Wnt-2, -4 and -5A/B. The expression patterns of the latter two zebrafish genes, designated ZfWnt4 and ZfWnt5 show considerable similarity with their homologues in other vertebrates; ZfWnt2, however, is expressed in the developing viscera in a pattern distinct from its closest murine homologue. In the light of the similarities and differences in the patterns of expression of these genes relative to their homologues in other vertebrates, we speculate on their possible functions. Received 24 October 1995 / Accepted in revised form: 16 January 1996 |
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Keywords: | Wnt Zebrafish Viscera Brain Neural tube Tailbud Presomitic mesoderm |
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