Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors |
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| Authors: | Siripurapu Uma Kolanos Renata Dukat Małgorzata Roth Bryan L Glennon Richard A |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA. |
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| Abstract: | Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently. |
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