Genetical genomics: the added value from segregation. |
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Authors: | R C Jansen J P Nap |
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Affiliation: | Plant Research International BV, PO Box 16, NL-6700 AA, Wageningen, The Netherlands. r.c.jansen@plant.wag-ur.nl |
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Abstract: | The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways. |
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