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Genetic complementation of steroid sulphatase after somatic cell hybridization of X-linked ichthyosis and multiple sulphatase deficiency |
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| Authors: | Ballabio A. Parenti G. Napolitano E. Di Natale P. Andria G. |
| Affiliation: | (1) Department of Pediatrics, 2nd Medical School, University of Naples, Naples, Italy;(2) Institute of Cellular and Molecular Biochemistry, 2nd Medical School, University of Naples, Naples, Italy;(3) Present address: Facoltá di Medicina e Chirurgia, Universitá di Reggio Calabria, Via S. Brunone di Colonia, Catanzaro, Italy |
| Abstract: | Summary Complementation studies of steroid sulphatase were carried out in the heterokaryon population of fibroblasts derived from patients with X-linked ichthyosis and multiple sulphatase deficiency. The activity of steroid sulphatase of the fused cell population was constantly higher (approximately 2–5 fold) than that of the unfused cocultivated cells. The occurrence of complementation further supports the hypothesis that at least two different loci control the expression of steroid sulphatase in the human genome. |
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