Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201-995 and is decreased by somatostatin antiserum |
| |
| Authors: | J Danguir |
| |
| Affiliation: | CNRS UA 637, Neurobiologie des Régulations, Collège de France, Paris. |
| |
| Abstract: | The chronic intracerebroventricular infusion of the somatostatin analogue SMS 201-995 resulted in a significant increase in daily food intake which was accompanied by an unexpected body weight loss. The neutralisation of central somatostatin using a specific somatostatin antiserum resulted in a significant decrease in daily food intake. These results suggest that endogenous somatostatin in the brain can drive feeding behavior and alter body weight. |
| |
| Keywords: | |
|
|
