Different alternative splicing patterns are subject to opposite selection pressure for protein reading frame preservation |
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Authors: | Feng-Chi Chen Trees-Juen Chuang |
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Institution: | (1) Division of Biostatistics and Bioinformatics, National Health Research Institutes, Miaoli County, 350, Taiwan;(2) Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan |
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Abstract: | Background Alternative splicing (AS) has been regarded capable of altering selection pressure on protein subsequences. Particularly,
the frequency of reading frame preservation (FRFP), as a measure of selection pressure, has been reported to be higher in
alternatively spliced exons (ASEs) than in constitutively spliced exons (CSEs). However, recently it has been reported that
different ASE types – simple and complex ASEs – may be subject to opposite selection forces. Therefore, it is necessary to
re-evaluate the evolutionary effects of such splicing patterns on frame preservation. |
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Keywords: | |
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