The effect of intracerebroventricular 5,7-dihydroxytryptamine on morphine analgesia is time-dependent |
| |
| Authors: | S Romandini E M Pich E Esposito A Z Kruszewska R Samanin |
| |
| Affiliation: | 1. Istituto di Ricerche Farmacologiche “Mario Negri” Via Eritrea, 62 - 20157 Milan, Italy;2. Visiting Scientist from Dept. of Pharmacodynamics, Medical Academy, Staszica 4, 20-081 Lublin, Poland;1. Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA;2. Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Oman;3. Ageing and Dementia Research Group, Sultan Qaboos University, Oman;4. Department of Nutritional Sciences, Qatar University, Qatar;1. Gladstone Institutes, San Francisco, CA, United States;2. Department of Biological Chemistry and Pharmacology, College of Medicine, Ohio State University, Columbus, OH, United States |
| |
| Abstract: | The analgesic effect of morphine in the tail immersion test was studied in rats three and ten days after intracerebroventricular 5,7-dihydroxytryptamine (5,7-DHT) given to selectively destroy serotonergic neurons. Morphine analgesia was reduced three but not ten days after the neurotoxin. Ten days after 5,7-DHT, the inhibiting effect of metergoline, a serotonin antagonist, on morphine analgesia was still present, suggesting that functional recovery of the serotonergic system may partly explain the different results. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
