Detection of Helicobacter pylori in bile of cats |
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Authors: | Boomkens Sacha Y Kusters Johannes G Hoffmann Gaby Pot Raymond G J Spee Bart Penning Louis C Egberink Herman F van den Ingh Ted S G A M Rothuizen Jan |
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Affiliation: | Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80154, 3508 TD Utrecht, The Netherlands. s.y.boomkens@vet.uu.nl |
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Abstract: | Lymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive (p=0.44). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir. |
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Keywords: | Helicobacter spp. Cholangitis Liver diseases Zoonose Cats |
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