Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group |
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| Authors: | Uesato Shinichi Kitagawa Manabu Nagaoka Yasuo Maeda Taishi Kuwajima Hiroshi Yamori Takao |
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| Institution: | Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, 564-8680, Osaka, Japan. uesato@ipicku.kansai-u.ac.jp |
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| Abstract: | Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide. |
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