首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Coxsackievirus B3-resistant mice become susceptible in Se/vitamin E deficiency
Authors:Beck Melinda A  Williams-Toone Deitra  Levander Orville A
Institution:Departments of Nutrition and Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7220, USA. melinda_beck@unc.edu
Abstract:The severity of the heart damage caused by a coxsackievirus infection in mice is determined by several factors, including the genotype of the infecting virus as well as the genetic background of the infected host. Earlier work by us showed that the cardiovirulence of a given coxsackievirus genotype could be increased substantially by feeding the host a diet nutritionally deficient in either selenium or vitamin E. Here we report that host genetic background as a determinant of viral infection outcome is superseded by feeding the host a diet nutritionally deficient in both selenium and vitamin E. Mice of the C57Bl/6 strain, normally resistant to coxsackievirus B3-induced myocarditis, become susceptible when fed such a doubly deficient diet. Our results demonstrate the powerful influence of host nutritional status on the course of viral infection compared to other variables traditionally considered to play major roles in determining the extent of virally induced inflammatory heart disease.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号