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Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. |
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| Authors: | R Docampo A O Stoppani |
| Institution: | Institute de Química Biológica, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina |
| Abstract: | Addition of nifurtimox (a nitrofuran derivative) to Trypanosoma cruzi culture (epimastigote) forms induced an increase in the respiratory rate and the release of H2O2 from the whole cells to the suspending medium. Growth-inhibiting concentrations of nifurtimox were able to stimulate O2? production by the T. cruzi mitochondrial fraction supplemented with NADH (or succinate), and also to enhance the generation of O2? by the microsomal fraction with NADPH as reductant. |
| Keywords: | To whom all correspondence should be addressed at Institute de Química Biológica Facultad de Medicina Universidad de Buenos Aires Paraguay 2155 1121-Buenos Aires Argentina |
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