Functional implications of dendritic voltage-dependent conductances. |
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| Authors: | W E Crill |
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| Affiliation: | Department of Physiology and Biophysics, University of Washington, Seattle 98195-7290, USA. |
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| Abstract: | Layer five pyramidal neurons of rat and cat neocortex have numerous ionic conductance mechanisms. The presence of these voltage-dependent conductances in the dendrites has a significant effect on the transmission of current from synaptic sites to the spike generating region in the proximal axon. Here we show such threshold activation of persistent sodium channels markedly amplifies current flowing through glutamate activated dendritic channels. |
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