| 醛固酮促进心室成纤维细胞增殖作用 |
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| 作者姓名： | Gong SZ Liu PQ Lu W Tan Z Fu SG Pan JY |
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| 作者单位： | 中山医科大学生理学教研室, |
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| 摘 要： | 目的探讨醛固酮促进心室成纤维细胞增殖作用。方法采用［
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| 关 键 词： | 醛固酮 螺旋内酯 [^3H]－TdR c－fosmRNA 成纤维细胞 心室 增殖作用 |
| 文章编号： | 1000-6834(2001)01-0064-04 |
| 修稿时间： | 2000年7月6日 |
The effect of aldosterone of promotion on proliferation of ventricular fibroblasts |
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| Gong SZ,Liu PQ,Lu W,Tan Z,Fu SG,Pan JY.The effect of aldosterone of promotion on proliferation of ventricular fibroblasts[J].Chinese Journal of Applied Physiology,2001,17(1):64-67. |
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| Authors: | Gong S Z Liu P Q Lu W Tan Z Fu S G Pan J Y |
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| Institution: | Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089. |
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| Abstract: | To study the effect of promoting aldosterone on proliferation of ventricular fibroblasts. Methods: Assay of ［3H］-TdR incorporat ion rate and RT-PCR were used.Results: Aldosterone could promote ［ 3H］-TdR incoporation of ventricular fibrolasts,the effective dose of aldost erone was among (1×10-9～1×10-6)mol/L,and had dose-dependent mann er,the c-fos gene was expressed after stimulated by aldosterone for 15 min,and studied the highest in 1 h,then reduced later.Spironolactone,aldosterone recepto r antagonist could block the effect of aldosterone.Conclusion: Aldos terone promotes the proliferation of ventricular fibroblasts,mediated by aldoste rone receptor. |
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| Keywords: | aldosterone spironolactone [3H] TdR c fos mRNA fibroblast |
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