|
|||||
|
|
Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16 |
|
| Authors: | Hishikawa Keiichi Marumo Takeshi Miura Shigeki Nakanishi Asato Matsuzaki Yumi Shibata Katsunori Kohike Hiroko Komori Takuya Hayashi Matsuhiko Nakaki Toshio Nakauchi Hiromitsu Okano Hideyuki Fujita Toshiro |
| Institution: | Department of Clinical Renal Regeneration, Graduate School of Medicine, University of Tokyo, Japan. hishikawa-tky@umin.ac.jp |
| Abstract: | Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16. |
| Keywords: | Stem cell Regenerative medicine Cadherin 16 |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |