Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication |
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Authors: | Chung Chungwon Lee Wonhee Loffredo John T Burwitz Benjamin Friedrich Thomas C Giraldo Vela Juan Pablo Napoe Gnankang Rakasz Eva G Wilson Nancy A Allison David B Watkins David I |
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Institution: | Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715-1299, USA. |
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Abstract: | Current assays of CD8+ T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8+ T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2. |
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