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In VivoEffects of Hepatocyte Growth Factor/Scatter Factor on Mouse Mammary Gland Development |
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| Authors: | Jeffrey Yant Lakjaya Buluwela Birunthi Niranjan Barry Gusterson Tahereh Kamalati |
| Institution: | aSection of Cell Biology and Experimental Pathology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom;bDepartment of Biochemistry and Medical Oncology, Charing Cross and Westminster Medical School, Fulham Palace Road, London, W6 8RF, United Kingdom |
| Abstract: | We have recently demonstrated the regulated expression ofHGF/SFand its receptor (c-met) during mouse mammary gland development together with the mitogenic, motogenic and morphogenic effects of exogenous HGF/SF on primary mammary epithelial cells in culture. This study was undertaken to analyze the influence of HGF/SF on reconstituted mouse mammary gland developmentin vivo.Here we report that overexpression of HGF/SF induces a range of alterations in the architecture of virgin mouse mammary gland. These include an enhancement of ductal end bud (mammary gland morphoregulatory control point) size and numbers and hyperplastic branching morphogenesis. These data are the first demonstration of the effects of HGF/SF on mammary epitheliumin vivo. |
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