Fractionation of neurophysin by molecular-sieve and ion-exchange chromatography |
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Authors: | M D Hollenberg and D B Hope |
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Institution: | Department of Pharmacology, University of Oxford |
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Abstract: | Neurophysin has been separated into seven distinct protein fractions. One of these components had no hormone-binding activity. The fractions that had hormone-binding activity were similar in amino acid composition: their cystine content was in the range 11·5–14·5%. The major component, neurophysin-M, was distinguished from the protein isolated by van Dyke by the presence of methionine and the absence of histidine. Neurophysin-M binds both oxytocin and vasopressin with similar affinities. |
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