| 脊髓提取液对培养脊髓神经细胞中GABA能及DYN能神经元突起生长的影响 |
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| 引用本文： | 梁哲,农艺.脊髓提取液对培养脊髓神经细胞中GABA能及DYN能神经元突起生长的影响[J].实验生物学报,1997,30(2):173-181. |
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| 作者姓名： | 梁哲 农艺 |
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| 摘 要： | 本文以体外培养的小鼠脊髓神经元为模型研究了人胚脊髓提取液对Ｅ１２－１５小鼠脊髓中ＧＡＢＡ能神经元和ＤＮＹ能神经元的突起生长的营养作用，结果发现人胚脊髓提取液在蛋白浓度为２５０μｇ／ｍｌ时对ＧＡＢＡ能神经元的突起生长无营养作用，但对ＤＮＹ能神经元的突起生长有显著的促进作用。提示了人胚脊髓提取液中有促进神经元突起生长的营养物质，且对特定胎龄的不同的神经元有不同的作用。
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| 关 键 词： | 脊髓提取液 神经细胞 γ氨基丁酸 强啡肽 神经元 |
Effects of spinal cord extract on neurite growth of GABAergic and dynergic neurons of spinal cord in vitro] |
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| Z Liang,Y Nong,H Yang,H J Wang,X Bao,G Ju.Effects of spinal cord extract on neurite growth of GABAergic and dynergic neurons of spinal cord in vitro][J].Acta Biologiae Experimentalis Sinica,1997,30(2):173-181. |
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| Authors: | Z Liang Y Nong H Yang H J Wang X Bao G Ju |
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| Institution: | Fourth Military Medical University, Neuroscience Research Institute of PLA, Xian. |
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| Abstract: | We use the crude extract from human fetal spinal cord to study the effect of endogenous substances of the spinal cord on neurite growth of E 12-15 mouse GABAergic and DNYergic neurons of the spinal cord in vitro. The results indicated that the crude extract had no effect on GABAergic neurons but had markedly neurite-promoting effect on DNYergic neurons when the protein concentration of the crude extract was 250 micrograms/ml. It suggests that there are endogenous substances in the crude extract of the human fetal spinal cord, which can promote neurite growth of spinal cord neurons and this effect is neuron type specific at particular embryonic age. |
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