Complementary DNA Cloning and Chromosomal Mapping of a Novel Phosphatidylinositol Kinase Gene |
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| Authors: | Saito Toshiyuki; Seki Naohiko; Ishii Hideshi; Ohira Miki; Hayashi Akiko; Kozuma Sumie; Hori Tada-aki |
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| Institution: | 1Genome Research Group, National Institute of Radiological Sciences 4-9-1 Anagawa, Inage-ku, Chiba 263, Japan
2Laboratory of Gene Structure I, Kazusa DNA Research Institute 1532-3 Yana, Kisarazu, Chiba 292, Japan |
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| Abstract: | A cDNA for a putative new member for phosphatidylinositol kinasefamily was cloned from an adult human whole brain cDNA library.The predicted translation product was composed of 961 aminoacid residues and contained a sequence feature characteristicfor lipid/protein kinases. The messenger RNA was ubiquitouslyexpressed in various tissues, while relatively higher expressionwas observed in heart, skeletal muscle and testis. The chromosomallocation of the gene was determined by fluorescence in situhybridization and PCR-based analyses with both a human/rodentmonochromosomal hybrid cell panel and a radiation hybrid mappingpanel. |
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| Keywords: | PI4 kinase RT-PCR 1q21 |
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