Screening of a Saccharomyces cerevisiae nonessential gene deletion collection for altered susceptibility to a killer peptide |
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| Authors: | Conti Stefania Magliani Walter Giovati Laura Libri Irene Maffei Domenico Leonardo Salati Antonella Polonelli Luciano |
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| Institution: | Dipartimento di Patologia e Medicina di Laboratorio, Sezione di Microbiologia, University of Parma, Parma, Italy. |
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| Abstract: | Approximately 4,800 Saccharomyces cerevisiae mutants deleted for nonessential genes were screened for alterations in susceptibility to a synthetic killer peptide (KP). None of the tested strains, including mutants resistant to conventional antifungal drugs, showed increased or decreased susceptibility to KP in comparison with the parental strain. The results may reflect the peculiar mechanism of action of KP and claim the possible avoidance of vital resistant mutants. |
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