Effect of streptozotocin-induced diabetes in neonatal rat on bile acid pool changes in adult life: selective sensitivity in females |
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| Authors: | H E Wey R L Yunker P Harris M T Subbiah |
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| Affiliation: | 1. Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 USA;2. Department of Pathology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 USA;3. Childrens Hospital Research Foundation, Cincinnati, Ohio 45267 USA |
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| Abstract: | The effect of streptozotocin-induced diabetes in neonatal rat on the bile acid pool and composition during adult life was investigated. Unlike the effect of diabetes in adult rats (where bile acid pool increases markedly), neonatal diabetes caused a reduction in bile acid pool in adult life in females (but not in males) with significant reduction in both cholic and chenodeoxycholic acids. Upon challenge with dietary cholesterol, only the female diabetic rat responded with a further reduction in total bile acid pool. These studies demonstrate a selective sensitivity in the female diabetic rat with regard to diabetes-induced changes in bile acid pool. |
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