A Mouse Homeo Box Gene, Hox-1.5, and the Morphological Locus, Hd, Map to within 1 Cm on Chromosome 6 |
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| Authors: | Beverly A Mock Lawrence A D'Hoostelaere Roberta Matthai and Konrad Huppi |
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| Institution: | Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 |
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| Abstract: | Mo-10, a homeo box-containing sequence in the Hox-1 complex of genes referred to as Hox-1.5, was found to be polymorphic in inbred and wild mice, and a strain distribution of three allelic forms of Hox-1.5 are reported. The position of Hox-1.5 was mapped in backcross experiments to within 1 cM of the hypodactyly locus on chromosome 6. This identifies the Hd mutation as a useful model for the examination of homeo box expression during mammalian development. |
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