Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism |
| |
Authors: | Norell M C Andersson H S Nicholls I A |
| |
Institution: | Bioorganic Chemistry Laboratory, University of Kalmar, Sweden. |
| |
Abstract: | The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non-imprinted (reference) polymers have been observed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |