An oxyanion-hole selective serine protease inhibitor in complex with trypsin. |
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| Authors: | Jian Cui Fatima Marankan Wentao Fu David Crich Andrew Mesecar Michael E Johnson |
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| Affiliation: | Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, 900 S. Ashland Avenue, M/C 870, Chicago, IL 60607-7173, USA. |
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| Abstract: | p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole. |
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