Conjugated linoleic acid reduces body fats and cytokine levels of mice |
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Authors: | Akahoshi Asuka Goto Yuki Murao Kayoko Miyazaki Tomoko Yamasaki Masao Nonaka Michiko Yamada Koji Sugano Michihiro |
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Affiliation: | Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan. a-asuka@pu-kumamoto.ac.jp |
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Abstract: | In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-alpha and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned. |
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