Immunohistochemical evaluation of bcl-2, ER-alpha,caspase -3, -8, -9, PCNA and Ki-67 expressions in canine mammary carcinomas |
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| Authors: | A Aydogan O Ozmen M Haligur C Sipahi D Ileri A Haligur |
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| Institution: | 1. University of Cukurova, Faculty of Ceyhan Veterinary Medicine, Department of Pathology, Adana;2. University of Mehmet Akif Ersoy, Faculty of Veterinary Medicine, Department of Pathology, Burdur;3. University of Mehmet Akif Ersoy, Faculty of Veterinary Medicine, Department of Animal Health Economics and Management, Burdur;4. University of Cukurova, Faculty of Ceyhan Veterinary Medicine, Department of Anatomy, Adana, Turkey |
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| Abstract: | We investigated the expression of bcl-2, estrogen receptor alpha (ER-alpha), caspase-3, ?8, ?9, proliferating cell nuclear antigen (PCNA) and Ki-67 in canine mammary carcinomas. We used 65 paraffin embedded and re-diagnosed archival canine mammary tumor samples to which we applied the routine streptavidin-biotin-peroxidase technique. Seventeen cases were re-diagnosed as tubulopapillary carcinoma, 31 were re-diagnosed as complex carcinoma and 17 were re-diagnosed as carcinosarcoma. Differences of expression of bcl-2 and PCNA were statistically significant according to tumor type. Differences in expression of ER-alpha, caspase-3, ?8, ?9 and Ki-67 were not statistically significant. Differences of expression of bcl-2 and PCNA were statistically significant compared to ER-alpha, caspase-3, ?8, ?9 and Ki-67 in carcinosarcomas. We report the prognostic significance of bcl-2 and PCNA expression in canine mammary carcinosarcomas. |
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| Keywords: | bcl-2 canine carcinoma caspase dogs ER-alpha histopathology immunohistochemistry Ki-67 mammary gland PCNA |
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