血清尿素氮、碱性磷酸酶与儿童营养不良的相关性分析

摘要 目的：探讨血清尿素氮（BUN）、碱性磷酸酶（AKP）与儿童营养不良的相关性。方法：选择2017年10月至2022年10月我院接诊的108例儿童，根据是否存在营养不良将受试儿分为营养不良组（38例）和营养良好组（70例）。检测血清BUN、AKP水平，分析BUN、AKP与受试儿身体组分的相关性。多因素Logistic回归分析影响儿童营养不良的因素，受试者工作特征曲线（ROC）分析BUN、AKP诊断儿童营养不良的价值。结果：营养不良组血清BUN、AKP水平，体脂百分含量（fat percentage，F%）、总体脂肪（TBF）、瘦体重（LBM）低于营养良好组（P＜0.05）。儿童血清BUN、AKP水平与F%、TBF、LBM呈正相关（P＜0.05）。消化不良是儿童营养不良的危险因素（P＜0.05），出生体质量、BUN、AKP、LBM是儿童营养不良的保护因素（P＜0.05）。联合BUN和AKP诊断儿童营养不良的曲线下面积为0.879，高于单独BUN和AKP诊断（P＜0.05）。结论：营养不良儿童血清BUN、AKP水平降低，且与身体组分改变和营养不良风险增加有关，联合检测血清BUN和AKP水平有助于评估儿童营养不良风险。

Correlation Analysis of Serum Urea Nitrogen, Alkaline Phosphatase and Childhood Dystrophy

ABSTRACT Objective: To investigate the correlation between serum urea nitrogen (BUN), alkaline phosphatase (AKP) and childhood dystrophy. Methods: 108 children admitted to the pediatric health clinic of our hospital from October 2017 to October 2022 were selected and divided into malnutrition group (38 cases) and good nutrition group (70 cases) according to whether there was malnutrition. Serum BUN and AKP levels were detected, and the correlation between BUN and AKP and body components of tested children was analyzed. Multivariate Logistic regression was used to analyze the factors affecting childhood dystrophy, and receiver operating characteristic curve (ROC) was used to analyze the value of BUN and AKP in diagnosing childhood dystrophy. Results: The levels of BUN, AKP, body fat percentage (F%), total fat (TBF) and lean body weight (LBM) in malnutrition group were lower than those in good nutrition group (P<0.05). Serum BUN and AKP levels of children were positively correlated with F%, TBF and LBM (P<0.05). Dyspepsia was a risk factor for malnutrition in premature infants(P<0.05), and birth weight, BUN, AKP and LBM were protective factors for childhood dystrophy(P<0.05). The area under the curve of combined BUN and AKP diagnosis of childhood dystrophy was 0.879, which was higher than that of single BUN and AKP diagnosis(P<0.05). Conclusion: The serum BUN and AKP levels of childhood dystrophy are decreased, which is associated with changes in body composition and increased risk of malnutrition in preterm infants. The combined detection of serum BUN and AKP levels is helpful to assess the risk of childhood dystrophy.