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Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses |
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| Authors: | Cristina Parolin Alessandra Borsetti Hyeryun Choe Michael Farzan Peter Kolchinsky Michael Heesen Qing Ma Craig Gerard Giorgio Palú Martin E Dorf Timothy Springer and Joseph Sodroski |
| Institution: | Cristina Parolin, Alessandra Borsetti, Hyeryun Choe, Michael Farzan, Peter Kolchinsky, Michael Heesen, Qing Ma, Craig Gerard, Giorgio Palú, Martin E. Dorf, Timothy Springer, and Joseph Sodroski |
| Abstract: | The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein. |
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