Fine mapping a quantitative trait locus on horse chromosome 2 associated with radiological signs of navicular disease in Hanoverian warmblood horses |
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Authors: | M. S. Lopes,U. Diesterbeck,A. da Câ mara Machado, O. Distl |
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Affiliation: | Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany;. Department of Agriculture, Biotechnology Centre of Azores, University of Azores, Terra-Chã, 9701-851 Angra do Heroísmo, Portugal |
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Abstract: | Navicular disease or podotrochlosis is one of the main causes of progressive forelimb lameness in warmblood horses. The objective of this study was to refine a quantitative trait locus on horse chromosome 2 for radiological alterations in the contour of the navicular bone (RAC) in Hanoverian warmblood horses. Genotyping was performed in 192 Hanoverian warmblood horses from 17 paternal half-sib groups. The marker set was extended to 58 informative microsatellites including nine newly developed microsatellites. QTL for RAC could be delineated at 32.50–43.13 Mb and a further new QTL for RAC could be identified at 59.08–65.14 Mb. The markers ABGe342 and ABGe343 reached the highest multipoint Z mean and LOD scores at 34.42 and 35.23 Mb with genome-wide error probabilities of P = 0.013 and P = 0.064. In addition, significant associations of markers and haplotypes within the QTL could be shown. The results support the location of the QTL on ECA2 associated with RAC. This work is a further step towards the development of a marker test for navicular disease in Hanoverian warmblood horses. |
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Keywords: | horse microsatellite navicular disease quantitative trait locus |
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