Protection against CD95-mediated apoptosis by inorganic mercury in Jurkat T cells. |
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| Authors: | M J Whitekus R P Santini A J Rosenspire M J McCabe |
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| Affiliation: | Institute of Chemical Toxicology, Detroit, MI 48201, USA. |
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| Abstract: | Dysregulation of CD95/Fas-mediated apoptosis has been implicated as a contributing factor in autoimmune disorders. Animal studies clearly have established a connection between mercury exposure and autoimmune disease in rodents, while case reports have suggested a link between accidental mercury contamination and autoimmune disease in humans. The mechanism(s) for these associations are poorly understood. Using the Jurkat cell model, we have found that low levels (
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