Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity |
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| Authors: | Tenório Rômulo P Carvalho Cristiane S Pessanha Carla S de Lima José G de Faria Antônio R Alves Antônio J de Melo Edésio J T Góes Alexandre J S |
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| Institution: | Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50670-901, Brazil. |
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| Abstract: | Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. |
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