Different effects of methionine-enkephalin on paw edema in two inbred rat strains |
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Authors: | Stanojević Stanislava Radulović Jelena Kovacević-Jovanović Vesna Vujić Vesna Dimitrijević Mirjana |
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Affiliation: | Branislav Jankovi? Immunology Research Center, Torlak Institute of Immunology and Virology, 458 Vojvode Stepe, 11152 Belgrade, Yugoslavia. canac@eunet.yu |
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Abstract: | The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexamine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains. |
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