Carbocyclic phosphonate analogs of 2′,3′-dideoxyadenosine-5′-monophosphate as substrates of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetate |
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| Authors: | Jean-Franois Nav Dominique Wolff-Kugel Serge Halazy |
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| Institution: | Marion Merrell Dow Research Institute, 16, rue d'Ankara 67009 Strasbourg, France |
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| Abstract: | Several carbocyclic phosphonate analogs of 2′,3′-dideoxyadenosine-5′-monophosphate (ddAMP) were pyrophosphorylated by E. coli 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase in the presence of PRPP. Structure-activity relationships are discussed. |
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