For Parkin,it's not all or nothing |
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| Authors: | Evgeny Shlevkov Thomas L Schwarz |
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| Affiliation: | F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA |
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| Abstract: | Mitochondria accumulate damage over time, which can lead to impairment of cell function by excessive production of reactive oxygen species. The PINK1/Parkin pathway therefore monitors the quality of the mitochondrial population and stimulates the elimination of depolarized organelles by mitophagy. In this issue of The EMBO Journal, McLelland et al ( 2014 ) show that this pathway also responds to mild oxidative damage, and instead of inducing mitophagy, allows oxidized proteins to be sorted into mitochondria‐derived vesicles (MDVs) that are transported to lysosomes. |
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