ADIPOQ gene polymorphisms and cancer risk: A meta-analysis |
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Authors: | Yuan Yang Fan Zhang Rongjing Ding Laura Skrip Yang Wang Han Lei Dayi Hu |
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Institution: | 1. First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;2. Department of Maternal and Child Health, School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China;3. Heart Center of Peking University People’s Hospital, Beijing 100044, China;4. Department of Biostatistics, School of Public Health, Yale University, 60 College Street, P.O. Box 208034, New Haven, CT 06520, USA |
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Abstract: | The results of studies investigating the association between ADIPOQ gene polymorphisms and risk of cancer have been inconsistent and often contradictory. The present meta-analysis was conducted in order to overcome the limitations of any individual study and to provide a more precise overall effect estimate. Relevant studies were identified by searching PubMed and Embase for articles published through May 2012. The strength of the relationship between the ADIPOQ gene and risk of cancer was assessed using odds ratios (ORs). Either a fixed-effects or a random-effects model was used to calculate the overall risk estimates. Fifteen studies were included and five SNPs were considered. A significant association was found between SNP rs2241766 and risk of cancer in the recessive genetic model (OR: 0.768, 95% CI: 0.626, 0.942], P = 0.011); a significant relationship was also found between SNP rs1501299 and risk of cancer in both an allele contrast (OR: 0.141, 95%CI: 0.113, 0.176], P < 0.001) and the dominant genetic model (OR: 0.904, 95%CI: 0.830, 0.985], P = 0.021); no association was found with the rs266729, rs822395, or rs822396 SNPs. Adjusted ORs were also considered, but no statistically significant association was found in homozygote contrasts for any of the five SNPs after adjustment. Our results suggest that two polymorphisms, SNP rs2241766 and SNP rs1501299, of the ADIPOQ gene may be associated with reduced risk of cancer. However, the overall strength of association is mild to moderate, and additional well-designed studies are needed to confirm the present conclusion. |
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