Relationship between FOXP3 positive populations and cytokine production in systemic lupus erythematosus |
| |
Authors: | Catuxa Prado Banesa de Paz Patricia López Jesús Gómez Javier Rodríguez-Carrio Ana Suárez |
| |
Institution: | 1. Department of Functional Biology, Immunology Area, Faculty of Medicine, C/Julián Clavería s/n, University of Oviedo, Oviedo, Asturias, Spain;2. Department of Immunology, Hospital Universitario Central de Asturias, C/Julián Clavería s/n, Oviedo, Asturias, Spain |
| |
Abstract: | In this work we studied CD4+FOXP3+ populations in systemic lupus erythematosus (SLE) and the relationship with Th cytokine production. We found an increment in CD25?FOXP3+ population in SLE associated with CD4+ downregulation and disease progression. CD25low cells were also upregulated and showed increased percentages of FOXP3+ and CD127?/low cells, supporting the activated status of SLE lymphocytes. Despite the normal levels of CD25highFOXP3+ cells, the negative correlations observed in controls with the frequency of IFNγ, TNFα and IL-10 secreting cells were disrupted in patients, supporting a defective Treg function. Also, CD25high cells showed an altered balance in the production of these cytokines. In addition, CD25highFOXP3+ cells correlated directly with IL-17A and IL-8 but not with TGFβ in SLE. The increased proportion of IL-17+ cells among the CD25high subset and the positive correlation between IL-17 levels and Treg cells suggest a trans-differentiation of Treg into Th17 cells in SLE. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|