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Vaccine-related mumps infections in Thailand and the identification of a novel mutation in the mumps fusion protein
Authors:Sarah M Gilliland  Adrian Jenkins  Lauren Parker  Nongyao Somdach  Sirima Pattamadilok  Patcha Incomserb  Neil Berry  Silke Schepelmann  Philip Minor
Institution:1. Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK;2. Institute of Biological Products, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand;3. National Institute of Health, Department of Medical Sciences, Ministry of Health, Nonthaburi 11000, Thailand
Abstract:An outbreak of nine cases of mumps was reported from a total of 97 vaccinated nursing students at two medical colleges in Thailand in 2010, 16–26 days after administration of MMR vaccine containing the L-Zagreb mumps strain. Symptoms ranged in severity from fever and parotid swelling to orchitis. Clinical samples were obtained from seven patients and three were suitable for further study.Sequencing confirmed that the SH gene of the mumps virus in the unpassaged clinical specimens was identical to the L-Zagreb SH gene in the vaccine. Further analysis of the viral genome identified nucleotide position 5170 as a novel mutation which corresponds to an amino acid change in the fusion protein.This study provides another virologically confirmed example of mumps resulting from the L-Zagreb vaccine strain.
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