Chromosomal hypersensitivity in mutant MCN-151 mouse cells exposed to mitomycin C |
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Authors: | F Rosselli E Moustacchi |
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Institution: | Institut Curie, Section de Biologie, Paris, France. |
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Abstract: | After exposure to mitomycin C, the mouse lymphoma cell mutant MCN-151, previously shown to be sensitive to the toxic effect of the drug, demonstrates higher frequencies of chromatid-type aberrations and of aberrant cells in comparison to L5178Y cells. At any given dose of mitomycin C, the frequencies of chromosomal aberrations increased with time reaching a plateau in both cell strains, with the mutant in all cases being more sensitive than normal cells. |
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