Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo2,3-b]pyridin-2-one, 3-(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.