Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles |
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Authors: | Wood Edgar R Kuyper Lee Petrov Kimberly G Hunter Robert N Harris Philip A Lackey Karen |
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Institution: | GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. |
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Abstract: | The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo2,3-b]pyridin-2-one, 3-(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed. |
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