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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles
Authors:Wood Edgar R  Kuyper Lee  Petrov Kimberly G  Hunter Robert N  Harris Philip A  Lackey Karen
Affiliation:GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
Abstract:The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.
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