Increased furan tolerance in Escherichia coli due to a cryptic ucpA gene |
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| Authors: | Wang Xuan Miller Elliot N Yomano Lorraine P Shanmugam K T Ingram Lonnie O |
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| Affiliation: | Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA. |
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| Abstract: | Expression arrays were used to identify 4 putative oxidoreductases that were upregulated (>3-fold) by furfural (15 mM, 15 min). Plasmid expression of one (ucpA) increased furan tolerance in ethanologenic strain LY180 and wild-type strain W. Deleting ucpA decreased furfural tolerance. Although the mechanism remains unknown, the cryptic ucpA gene is now associated with a phenotype: furan resistance. |
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