Synthesis of L-asparaginase bySerratia marcescens (Nima) |
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| Authors: | C. P. Sukumaran D. V. Singh P. R. Mahadevan |
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| Affiliation: | (1) Central Research Laboratory, Indian Drugs and Pharmaceuticals Limited, Rishikesh, 249 202 Virbhadra;(2) Present address: The Foundation for Medical Research, 84-A, R. G. Thadani Marg, Worli, 400 018 Bombay |
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| Abstract: | The production of L-asparaginase by two mutants ofSerratia marcescens grown on 14 different media was studied. The enzyme content increased from trace levels to 2.4 international units per ml when the organisms were grown in glycerol-peptone yeast extract medium. Glucose was the best carbon source under aerobic conditions. The enzyme content increased when L-asparagine was present in the growth medium. |
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| Keywords: | L-asparaginase Serratia marcescens growth media |
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