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Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides |
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| Authors: | Zhuravel' Irina O Kovalenko Sergiy M Ivachtchenko Alexandre V Balakin Konstantin V Kazmirchuk Victor V |
| Institution: | aNational Pharmaceutical University, Kharkiv, Ukraine bInstitute of Combinatorial Organic Chemistry, Kharkiv, Ukraine cChemical Diversity Labs, Inc., San Diego, CA, USA dMechnikov Institute of Microbiology and Immunology of UAMS, Kharkiv, Ukraine |
| Abstract: | Several novel 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano2,3-c]pyridine-3-(N-aryl) carboxamides were prepared by reaction of pyridoxal hydrochloride with various N-arylcyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5–25 μg/mL), displaying comparable or even better efficacy than the standard drugs. |
| Keywords: | Pyrano[2 3-c]pyridine Compound library |
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