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| 用近红外光拓扑图技术实时跟踪脑血流变化 | |
| 引用本文： | 陈卫国,李鹏程,卢广,胡波. 用近红外光拓扑图技术实时跟踪脑血流变化[J]. 生物物理学报, 2000, 16(3): 613-617 |
| 作者姓名： | 陈卫国 李鹏程 卢广 胡波 |
| 作者单位： | 1. 华中理工大学生命科学与技术学院,湖北,武汉,430074 2. 中国科学院武汉分院磁共振和原子、分子物理国家重点实验室,湖北,武汉,430074 3. 同济医科大学附属协和医院神经内科,湖北,武汉,430030 |
| 基金项目： | 国家自然科学基金资助!(批准号 :39770228) |
| 摘 要： | 用近红外光大脑拓扑图技术（ｎｅａｒ－ｉｎｆｒａｒｅｄ ｃｅｒｅｂｒａｌ ｔｏｐｏｇｒａｐｈｙ，ＮＩＲＳ ｔｏｐｏｇｒａｐｈｙ），对大鼠大脑中动脉线栓梗塞模型的皮层缺血部位成像。利用氧合血红蛋白和去氧血红蛋白对近红外光吸收峰值波长分别为８５０ｎｍ和７６０ｎｍ的原理，制作了ＮＩＲＳ拓扑仪。分别用ＮＩＲＳ拓扑仪、磁共振成像和解剖样本染色对１０只ＳＤ雄性大鼠大脑皮层缺血部位进行成像。结果表明，ＮＩＲＳ拓扑 |
| 关 键 词： | 近红外光谱 拓扑图 脑梗塞 预测 实时 |
NEAR INFRARED SPECTROSCOPY TOPOGRAPHY TRACING THE CEREBRAL HEMODYNAMIC CHANGES IN REAL TIME |
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| CHEN Wei-guo,LI Peng-cheng,LU Guang,HU Bo. NEAR INFRARED SPECTROSCOPY TOPOGRAPHY TRACING THE CEREBRAL HEMODYNAMIC CHANGES IN REAL TIME[J]. Acta Biophysica Sinica, 2000, 16(3): 613-617 | |
| Authors: | CHEN Wei-guo LI Peng-cheng LU Guang HU Bo |
| Abstract: | Based on the absorption wavelength of oxyhemoglobin (850nm) and deoxyhemoglobin (760nm) a near infrared spectroscopy (NIRS) and the relative software to measure cerebral hemodynamic changes have been constructed.The cortical ischemia area reflected in the NIRS was compared with that in the magnetic resonance imaging (MRI) and the anatomical sample of the same rat. The results show that there are significant correlations between NIRS topography and MRI (r=0.82,p<0.05) and between NIRS and anatomical sample (r=0.89,p<0.01). |
| Keywords: | Near infrared spectroscopy Topography Cerebral infarction Prediction In real time |
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