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Coupling of ligands to insoluble matrices via aldehyde groups |
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| Authors: | R. Koelsch M. Fusek Z. Hostomská J. Lasch J. Turková |
| Affiliation: | (1) Institute of Biochemistry, Faculty of Medicine, Martin-Luther-University, Halle/Saale, German Democratic Republic;(2) Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia |
| Abstract: | Summary The linkages formed between glutaraldehyde-activated solid supports and ligands containing amino groups are more stable than bonds formed after oxidation of glucose residues of the support to aldehyde groups. These results show that different types of chemical bonds are formed by the two kinds of activated support. If glutaral dehyde is used for the activation the reduction step is not necessary.Dedicated to Professor Dr. Georg Manecke on the occasion of his 70th birthday |
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