Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides |
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| Authors: | Komatsu Hironori Araki Tadashi |
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| Institution: | Catalysis Science Laboratory, Mitsui Chemicals, Inc., Chiba, Japan. |
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| Abstract: | Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5). |
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