Distribution of zinc in the substantia nigra of rats treated with 6-hydroxydopamine |
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Authors: | Atsushi Takeda Jinko Sawashita Sachiyo Takefuta Shoji Okada |
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Affiliation: | (1) Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422 Shizuoka, Japan |
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Abstract: | To study the relationship between tissue accumulation of Zinc (Zn) and neurodegeneration in the nigrostriatal dopaminergic pathway,65Zn distribution in this pathway was examined after unilateral injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra of rats. When65ZnCl2 was intravenously injected 4 days after treatment with 6-OHDA,65Zn was concentrated in the ipsilateral substantia nigra 6 days after65Zn injection. On the other hand, 19 d after treatment with 6-OHDA,65Zn distribution in the ipsilateral substantia nigra was decreased to the level of the contralateral one. When NH4 99TcO4, which cannot go through the blood-brain barrier, was injected into rats 4 d after treatment with 6-OHDA,99Tc was concentrated in the ipsilateral substantia nigra 30 min after99Tc injection, but no longer detectable 6 d after injection. These results suggest that Zn is necessary for a repair process called replacement gliosis after the death of neurons and that excess Zn does not accumulate in the lesion after completion of the gliosis. |
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Keywords: | 6-Hydroxydopamine substantia nigra zinc dopaminergic pathway neurodegeneration |
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